Fanci^em2Szh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fanci^em2Szh
• Name: Fanconi anemia, complementation group I; endonuclease-mediated mutation 2, Shidou Zhao
• MGI ID: MGI:6827419
• Gene: Fanci Location: Chr7:79042056-79100013 bp, + strand Genetic Position: Chr7, 45.01 cM
• Alliance: Fanci^em2Szh page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 5 deleted 98 bp and produced a frameshift mutation (p.Pro103Cysfs*15). (J:312543)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fanci Mutation: 200 strains or lines available

References

• Original: J:312543 Xu L, et al., FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation. Cell Death Dis. 2021 Aug 9;12(8):780
• All: 2 reference(s)