Paxbp1^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Paxbp1^tm1.1Nju
• Name: PAX3 and PAX7 binding protein 1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6827438
• Synonyms: Paxbp1^flox
• Gene: Paxbp1 Location: Chr16:90810925-90841267 bp, - strand Genetic Position: Chr16, 52.3 cM, cytoband C3.3
• Alliance: Paxbp1^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304562
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 7 and a second loxP site into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 8 floxed. (J:304562)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paxbp1 Mutation: 46 strains or lines available

References

• Original: J:304562 Zhou S, et al., Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2021093118
• All: 3 reference(s)