Mirc4^tm1.1Biat
Targeted Allele Detail

Summary

• Symbol: Mirc4^tm1.1Biat
• Name: microRNA cluster 4, including Mir429 through Mir200b; targeted mutation 1.1, Biomodels Austria
• MGI ID: MGI:6828980
• Synonyms: 200a^flox
• Gene: Mirc4 Location: Chr4:156138362-156140207 bp Genetic Position: Chr4, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314874
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mirc4^tm1.1Biat involves 3 genes/genome features (Mir429, Mir200a, Mir200b) View all
• Mutation details: The targeting construct inserted a loxP site upstream of Mir200b and an FRT-flanked neomycin resistance cassette with a 3 loxP site downstream of Mir429. Flp-mediated recombination removed the selection cassette and left the cluster floxed. (J:314874)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc4 Mutation: 1 strain or line available

References

• Original: J:314874 Belgardt BF, et al., The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes. Nat Med. 2015;21(6):619-27
• All: 2 reference(s)