Tp(X)1Soff^{Tg(Myh11-icre/ERT2)1Soff}
Spontaneous Allele Detail

Summary

• Symbol: Tp(X)1Soff^{Tg(Myh11-icre/ERT2)1Soff}
• Name: transposition, Chr X, Offermanns 1; transgene insertion 1, Stefan Offermanns
• MGI ID: MGI:6830915
• Gene: Tp(X)1Soff Location: unknown Genetic Position: ChrX, Syntenic

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Spontaneous (Recombinase)
• Mutation: Translocation
• Tp(X)1Soff^{Tg(Myh11-icre/ERT2)1Soff} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh11 (MGI:102643)

• Mutation details: The mouse promoter from BAC clone 26630 was used to drive inducible icre expression in smooth muscle cells. An FRT-flanked beta-lactamase gene contained within the cre/ESR1 cassette was removed by flp mediated recombination. The transgene that originally integrated into Chr Y was found to to have translocated to Chr X in some female mice in the colony. The exact position is unknown. (J:248193)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh11 (mouse) Summary of all recombinase alleles driven by Myh11. Comparative matrix view of recombinase activities Alliance mouse Myh11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tp(X)1Soff Mutation: 1 strain or line available

References

• Original: J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8
• All: 3 reference(s)