Cgas^em2Nki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cgas^em2Nki
• Name: cyclic GMP-AMP synthase; endonuclease-mediated mutation 2, The Netherlands Cancer Institute
• MGI ID: MGI:6831066
• Synonyms: Cgas^em1Anda, Cgas^R241E
• Gene: Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Cgas^em2Nki page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: CRISPR-targeting replaced exon 2 with one in which a point mutation (AGA to CTC) in the inverted direction flanked by lox71 and lox66. (J:340265)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cgas Mutation: 24 strains or lines available

References

• Original: J:340265 Gulen MF, et al., cGAS-STING drives ageing-related inflammation and neurodegeneration. Nature. 2023 Aug;620(7973):374-380
• All: 1 reference(s)