Agtr2^em1(cre)Adk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Agtr2^em1(cre)Adk
• Name: angiotensin II receptor, type 2; endonuclease-mediated mutation 1, Annette D de Kloet
• MGI ID: MGI:6834781
• Synonyms: Agtr2^Cre, AT2R-Cre
• Gene: Agtr2 Location: ChrX:21350863-21355072 bp, + strand Genetic Position: ChrX, 16.71 cM
• Alliance: Agtr2^em1(cre)Adk page

Mutation origin

• Strain of Origin: C57BL/6J x SJL

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Agtr2^em1(cre)Adk expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Agtr2 (MGI:87966)

• Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a viral 2A oligopeptide sequence (T2A; mediates ribosomal skipping), an SV40 nuclear localization signal, and a Cre recombinase gene were inserted into the Agtr2 gene 3'UTR. (J:316137)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Agtr2 (mouse) Summary of all recombinase alleles driven by Agtr2. Alliance mouse Agtr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agtr2 Mutation: 11 strains or lines available

References

• Original: J:316137 Mohammed M, et al., Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice. Cardiovasc Res. 2021 Mar 16
• All: 1 reference(s)