Zfhx4^tm1.1Rnis
Targeted Allele Detail

Summary

• Symbol: Zfhx4^tm1.1Rnis
• Name: zinc finger homeodomain 4; targeted mutation 1.1, Riko Nishimura
• MGI ID: MGI:6834794
• Gene: Zfhx4 Location: Chr3:5283586-5480917 bp, + strand Genetic Position: Chr3, 1.96 cM, cytoband A1
• Alliance: Zfhx4^tm1.1Rnis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316165
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 7 and a loxP site was inserted downstream of exon 8 via homologous recombination. Cre-mediated recombination removed the neo cassette and exons 7 and 8. (J:316165)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfhx4 Mutation: 155 strains or lines available

References

• Original: J:316165 Nakamura E, et al., Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Commun Biol. 2021 Nov 3;4(1):1258
• All: 1 reference(s)