Rnf138^tm1.1Lwan
Targeted Allele Detail

Summary

• Symbol: Rnf138^tm1.1Lwan
• Name: ring finger protein 138; targeted mutation 1.1, Linfang Wang
• MGI ID: MGI:6834806
• Gene: Rnf138 Location: Chr18:21134398-21161281 bp, + strand Genetic Position: Chr18, 11.73 cM, cytoband A2
• Alliance: Rnf138^tm1.1Lwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted downstream of exon 2 before the second loxP site. Exon 2 and the selection cassette were removed via cre-mediated recombination. Exon 2 deletion results in a downstream frameshift. (J:315603)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf138 Mutation: 78 strains or lines available

References

• Original: J:315603 Xu L, et al., Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice. Cell Death Dis. 2017 May 18;8(5):e2795
• All: 2 reference(s)