Slc4a5^tvrm77
Chemically induced Allele Detail

Summary

• Symbol: Slc4a5^tvrm77
• Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5; translational vision research model 77
• MGI ID: MGI:6835638
• Gene: Slc4a5 Location: Chr6:83196810-83281927 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Slc4a5^tvrm77 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: This ENU-induced T to A transversion in intron 3 disrupts a 5-prime splice donor sequence and has been shown to cause two novel splicing events in retinal pigment epithelium, one of which includes a portion of the intron downstream of exon 3 and is predicted to encode a short N-terminal polypeptide with 11 non-native amino acids and premature stop codon, and the other of which exon 3 is skipped leading to premature termination. (J:321062)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a5 Mutation: 51 strains or lines available

References

• Original: J:166679 Won J, et al., Mouse model resources for vision research. J Ophthalmol. 2011;2011:391384
• All: 2 reference(s)