Fbxo42^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxo42^em1(IMPC)J
• Name: F-box protein 42; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6836768
• Gene: Fbxo42 Location: Chr4:140875224-140931373 bp, + strand Genetic Position: Chr4, 73.41 cM
• Alliance: Fbxo42^em1(IMPC)J page
• IMPC: Fbxo42 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ACTGTTGTAAAGTTAAGCCA and ATTTCCTCCAGACACAGACT, which resulted in a 452 bp deletion beginning at Chromosome 4 position 140,920,700 bp and ending after 140,921,151 bp (GRCm39/mm39). This mutation deletes ENSMUSE00001305721 (exon 5) and 298 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 168 and early truncation 19 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fbxo42 Mutation: 220 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)