Cenpvtm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Cenpvtm1c(EUCOMM)Hmgu |
Name: |
centromere protein V; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6838381 |
Synonyms: |
Cenp-Vfl |
Gene: |
Cenpv Location: Chr11:62415772-62430087 bp, - strand Genetic Position: Chr11, 38.43 cM, cytoband B2
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Alliance: |
Cenpvtm1c(EUCOMM)Hmgu page
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IMPC: |
Cenpv gene page |
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Mutant Cell Line: |
HEPD0517_1_G11 |
Germline Transmission: |
Earliest citation of germline transmission:
J:314905
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_gt2
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Mutation details: The L1L2_gt2 cassette was inserted at position 62424450 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 62425249. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:314905)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cenpv Mutation: |
60 strains or lines available
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Original: |
J:314905 Nabi D, et al., CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes. Nat Commun. 2021 Nov 11;12(1):6547 |
All: |
1 reference(s) |
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