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Cenpvtm1c(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Cenpvtm1c(EUCOMM)Hmgu
Name: centromere protein V; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:6838381
Synonyms: Cenp-Vfl
Gene: Cenpv  Location: Chr11:62415772-62430087 bp, - strand  Genetic Position: Chr11, 38.43 cM, cytoband B2
Alliance: Cenpvtm1c(EUCOMM)Hmgu page
IMPC: Cenpv gene page
Mutation
origin
Mutant Cell Line:  HEPD0517_1_G11
Germline Transmission:  Earliest citation of germline transmission: J:314905
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 62424450 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 62425249. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:314905)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cenpv Mutation:  60 strains or lines available
References
Original:  J:314905 Nabi D, et al., CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes. Nat Commun. 2021 Nov 11;12(1):6547
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory