Ahcy^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ahcy^em1Cya
• Name: S-adenosylhomocysteine hydrolase; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6838413
• Synonyms: Ahcy^em1Cgen
• Gene: Ahcy Location: Chr2:154901230-154916417 bp, - strand Genetic Position: Chr2, 76.94 cM
• Alliance: Ahcy^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exons 4 to 9 produced a null allele. (J:298071)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ahcy Mutation: 29 strains or lines available

References

• Original: J:298071 Xiao Y, et al., Inhibition of S-Adenosylhomocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway. Circulation. 2019 May 7;139(19):2260-2277
• All: 1 reference(s)