Ncl^em1Mfz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ncl^em1Mfz
• Name: nucleolin; endonuclease-mediated mutation 1, Mike Fainzilber
• MGI ID: MGI:6842504
• Gene: Ncl Location: Chr1:86272441-86287122 bp, - strand Genetic Position: Chr1, 43.94 cM
• Alliance: Ncl^em1Mfz page

Mutation origin

• Strain of Origin: (BALB/cAnNHsd x C57BL/6NHsd)F1/Hsd

Mutation description

• Allele Type: Endonuclease-mediated (Altered localization)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 13 deleted the GAR binding domain responsible for subcellular localization. (J:312459)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncl Mutation: 30 strains or lines available

References

• Original: J:312459 Doron-Mandel E, et al., The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization. EMBO J. 2021 Oct 18;40(20):e107158
• All: 1 reference(s)