Dppa4^tm1.1Reik
Targeted Allele Detail

Summary

• Symbol: Dppa4^tm1.1Reik
• Name: developmental pluripotency associated 4; targeted mutation 1.1, Wolf Reik
• MGI ID: MGI:6842978
• Gene: Dppa4 Location: Chr16:48104096-48114600 bp, + strand Genetic Position: Chr16, 30.75 cM
• Alliance: Dppa4^tm1.1Reik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316936
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted upstream of exon 2 a loxP site and downstream of exon 2 a self-excising neomycin resistance cassette with a 3 prime loxP site. The final allele lacks the selection cassette. (J:316936)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Dppa4^tm1.1Reik/Dppa4^+ Tmem163^Tg(ACTB-cre)2Mrt/Tmem163^+	involves: C57BL/6 * FVB/N

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms Sex:
cellular	√
maternal effect	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dppa4 Mutation: 33 strains or lines available

References

• Original: J:316936 Kubinyecz O, et al., Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival. Development. 2021 Dec 15;148(24):dev200191
• All: 1 reference(s)