Selenow^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Selenow^{tm1c(EUCOMM)Wtsi}
• Name: selenoprotein W; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6845150
• Synonyms: SELENOW^tm1c
• Gene: Selenow Location: Chr7:15651133-15656296 bp, - strand Genetic Position: Chr7, 8.62 cM, cytoband A2
• Alliance: Selenow^{tm1c(EUCOMM)Wtsi} page

Mutation origin

• Mutant Cell Line: EPD0577_3_A05
• Germline Transmission: Earliest citation of germline transmission: J:317012
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 15653558 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 15654803. Flp-mediated recombination removed the FRT-flanked neo cassette leaving the critical exon(s) floxed. (J:317012)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenow Mutation: 18 strains or lines available

References

• Original: J:317012 Kim H, et al., Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nat Commun. 2021 Apr 15;12(1):2258
• All: 1 reference(s)