Lss^em1Zhaol
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lss^em1Zhaol
• Name: lanosterol synthase; endonuclease-mediated mutation 1, Ling Zhao
• MGI ID: MGI:6849722
• Synonyms: Lss^G589S
• Gene: Lss Location: Chr10:76367422-76392972 bp, + strand Genetic Position: Chr10, 39.1 cM
• Alliance: Lss^em1Zhaol page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting of exon 19 replaced GG with TC to produce the amino acid substitution of glycine to serine at position 589 (G589S). (J:316796)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lss Mutation: 29 strains or lines available

References

• Original: J:316796 Zhao M, et al., Defect of LSS Disrupts Lens Development in Cataractogenesis. Front Cell Dev Biol. 2021;9:788422
• All: 1 reference(s)