Unc5b^{tm1.1(cre/ERT2)Zjh}
Targeted Allele Detail

Summary

• Symbol: Unc5b^{tm1.1(cre/ERT2)Zjh}
• Name: unc-5 netrin receptor B; targeted mutation 1.1, Z Josh Huang
• MGI ID: MGI:6849725
• Synonyms: Unc5b-2A-Cre^ERT2, Unc5b-CreER
• Gene: Unc5b Location: Chr10:60598373-60667360 bp, - strand Genetic Position: Chr10, 31.52 cM, cytoband B4
• Alliance: Unc5b^{tm1.1(cre/ERT2)Zjh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317073
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Unc5b^{tm1.1(cre/ERT2)Zjh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Unc5b (MGI:894703)

• Mutation details: Using homologous recombination in ES cells, a T2A-CreERT2 cassette was inserted in-frame immediately before the stop codon of the mouse Unc5b gene. The Frt-Neo-Frt cassette in the founder line was removed by breeding with Flpe deleter mice. (J:317073)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Unc5b (mouse) Summary of all recombinase alleles driven by Unc5b. Comparative matrix view of recombinase activities Alliance mouse Unc5b gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc5b Mutation: 63 strains or lines available

References

• Original: J:317073 Dudok B, et al., Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Neuron. 2021 Dec 1;109(23):3838-3850.e8
• All: 3 reference(s)