Sfta3^{tm1.1(cre/ERT2)Eem}
Targeted Allele Detail

Summary

• Symbol: Sfta3^{tm1.1(cre/ERT2)Eem}
• Name: surfactant associated 3; targeted mutation 1.1, Edward E Morrisey
• MGI ID: MGI:6850124
• Synonyms: NANCI^creERT2:RFP, NANCI^{creERT2-TdTomato}
• Gene: Sfta3 Location: Chr12:56537213-56576205 bp, - strand Genetic Position: Chr12, 24.4 cM
• Alliance: Sfta3^{tm1.1(cre/ERT2)Eem} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243650
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Sfta3^{tm1.1(cre/ERT2)Eem} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sfta3 (MGI:2144804)

• Mutation details: The allele was constructed by inserting an expression cassette consisting of an IRES sequence, creERT2 cDNA linked to a 2A self-cleaving peptide sequence linked to a TdTomato cDNA, and a polyadenylated stop site into the first splice donor site of the Sfta3-ps gene. (J:243650)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sfta3 (mouse) Summary of all recombinase alleles driven by Sfta3. Comparative matrix view of recombinase activities Alliance mouse Sfta3 gene page

Expression

In Mice Carrying this Mutation:

192 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfta3 Mutation: 0 strains or lines available

References

• Original: J:243650 Herriges MJ, et al., The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis. Genes Dev. 2017 May 01;31(9):889-903
• All: 1 reference(s)