Tg(Gata1-cre/ERT2)L245Jeng
Transgene Detail

Summary

• Symbol: Tg(Gata1-cre/ERT2)L245Jeng
• Name: transgene insertion L245, James Douglas Engel
• MGI ID: MGI:6850167
• Synonyms: G1BCreERT2
• Transgene: Tg(Gata1-cre/ERT2)L245Jeng Location: unknown
• Alliance: Tg(Gata1-cre/ERT2)L245Jeng page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Gata1-cre/ERT2)L245Jeng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gata1 (MGI:95661)

• Mutation details: A tamoxifen-inducible CreER(T2) fusion gene was introduced to the start codon of the mouse Gata1 gene contained within BAC RP23-443E19. The modified BAC was introduced to C57BL/6J zygotes. Lines L245 and L259 were generated and shared similar profiles of the erythroid lineage-specific cre activities. The line L259 was used for the studies. The insertion site and copy number of the transgene are unknown. (J:315683)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gata1 (mouse) Summary of all recombinase alleles driven by Gata1. Comparative matrix view of recombinase activities Alliance mouse Gata1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:315683 Yu L, et al., An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation. Blood. 2021 Nov 4;138(18):1691-1704
• All: 1 reference(s)