Tg(DBH-SNCA)#Dwei
Transgene Detail

Summary

• Symbol: Tg(DBH-SNCA)#Dwei
• Name: transgene insertion, David Weinshenker
• MGI ID: MGI:6852559
• Synonyms: DBH-hSNCA
• Transgene: Tg(DBH-SNCA)#Dwei Location: unknown
• Alliance: Tg(DBH-SNCA)#Dwei page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(DBH-SNCA)#Dwei expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The human wild-type alpha-synuclein cDNA is under the control of noradrenergic neuron-specific human dopamine beta-hydroxylase promoter. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:296218)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:296218 Butkovich LM, et al., Transgenic Mice Expressing Human alpha-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease. J Neurosci. 2020 Sep 23;40(39):7559-7576
• All: 1 reference(s)