Sectm1a^em1Gcfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sectm1a^em1Gcfa
• Name: secreted and transmembrane 1A; endonuclease-mediated mutation 1, Guo-Chang Fan
• MGI ID: MGI:6852564
• Gene: Sectm1a Location: Chr11:120958233-120972046 bp, - strand Genetic Position: Chr11, 84.89 cM
• Alliance: Sectm1a^em1Gcfa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a deletion in exon 3. qRT-PCR confirmed absence of mRNA expression. (J:317204)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sectm1a Mutation: 23 strains or lines available

References

• Original: J:317204 Li Y, et al., Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRalpha signalling in macrophages. Cardiovasc Res. 2021 Feb 22;117(3):890-902
• All: 3 reference(s)