Tg(Gata1-cre/ERT2)2Mym
Transgene Detail

Summary

• Symbol: Tg(Gata1-cre/ERT2)2Mym
• Name: transgene insertion 2, Masayuki Yamamoto
• MGI ID: MGI:6852598
• Synonyms: MG-CreER^T2
• Transgene: Tg(Gata1-cre/ERT2)2Mym Location: unknown
• Alliance: Tg(Gata1-cre/ERT2)2Mym page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Gata1-cre/ERT2)2Mym expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gata1 (MGI:95661)

• Mutation details: The mouse BAC clone (RP23-443E19) containing the entire Gata1 locus is driven in hematopoietic cells by 659bp fragments consisting of the three regulatory elements of the Gata1 gene, G1HE, dbG, and CACCC elements combined mini-gene (MG). The expression cassette consisting of Cre/ERT2-polyA-Neo was inserted into the endogenous Gata1 initiating ATG by recombination. The correct clone was then used for Neo excision. Founder information and line numbers were not available. Two lines (Line 1 and 2) were established and used for the study. (J:243995)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gata1 (mouse) Summary of all recombinase alleles driven by Gata1. Comparative matrix view of recombinase activities Alliance mouse Gata1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243995 Yu L, et al., Derepression of the DNA Methylation Machinery of the Gata1 Gene Triggers the Differentiation Cue for Erythropoiesis. Mol Cell Biol. 2017 Apr 15;37(8)
• All: 1 reference(s)