Tg(Igkv3-5*-MYC)24Plbe
Transgene Detail

Summary

• Symbol: Tg(Igkv3-5*-MYC)24Plbe
• Name: transgene insertion 24, P Leif Bergsagel
• MGI ID: MGI:6856586
• Synonyms: Vk*MYC, VkMYC
• Transgene: Tg(Igkv3-5*-MYC)24Plbe Location: unknown Genetic Position: Chr17, Syntenic
• Alliance: Tg(Igkv3-5*-MYC)24Plbe page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igkv3-5*-MYC)24Plbe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector MN894515). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. Lines 11 and 24 (20 and 8 copies of the transgene, respectively, inserted chr11:6965780-7030487 with translocation of chr 7:68557535-68718226 sequence and chr17:91535994-91546658, mm39, respectively) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:131912)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Igkv3-5*-MYC)24Plbe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131912 Chesi M, et al., AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008 Feb;13(2):167-80
• All: 3 reference(s)