About   Help   FAQ
Tg(Igkv3-5*-MYC)DLoxP4Plbe
Transgene Detail
Summary
Symbol: Tg(Igkv3-5*-MYC)DLoxP4Plbe
Name: transgene insertion DLoxP4, P Leif Bergsagel
MGI ID: MGI:6856591
Synonyms: Tg(Igkv3-5*DLoxP-MYC)4Plbe, Vk*MYCDLoxP, VkMYCDLoxP
Transgene: Tg(Igkv3-5*-MYC)DLoxP4Plbe  Location: unknown  Genetic Position: Chr14, Syntenic
Alliance: Tg(Igkv3-5*-MYC)DLoxP4Plbe page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
  Tg(Igkv3-5*-MYC)DLoxP4Plbe involves 1 genes/genome features (Gm41210) View all
 
Tg(Igkv3-5*-MYC)DLoxP4Plbe expresses 1 gene
 
Mutation detailsThe mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. This vector lacks the loxP site found in Tg(Igkv3-5*-MYC)24Plbe. Line 4 inserted at chr14:74838906-74848613 (mm39) with deletion of intervening region. (J:94077, J:131912)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory