Tg(Igkv3-5*-MYC)DLoxP4Plbe
Transgene Detail
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Symbol: |
Tg(Igkv3-5*-MYC)DLoxP4Plbe |
Name: |
transgene insertion DLoxP4, P Leif Bergsagel |
MGI ID: |
MGI:6856591 |
Synonyms: |
Tg(Igkv3-5*DLoxP-MYC)4Plbe, Vk*MYCDLoxP, VkMYCDLoxP |
Transgene: |
Tg(Igkv3-5*-MYC)DLoxP4Plbe Location: unknown Genetic Position: Chr14, Syntenic
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Alliance: |
Tg(Igkv3-5*-MYC)DLoxP4Plbe page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Igkv3-5*-MYC)DLoxP4Plbe involves 1 genes/genome features (Gm41210)
View all
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Tg(Igkv3-5*-MYC)DLoxP4Plbe expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MYC (4609) |
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Mutation details: The mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. This vector lacks the loxP site found in Tg(Igkv3-5*-MYC)24Plbe. Line 4 inserted at chr14:74838906-74848613 (mm39) with deletion of intervening region.
(J:94077, J:131912)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015; |
All: |
5 reference(s) |
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