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Tg(Igkv3-5*-MYC)DLoxP4Plbe
Transgene Detail
Summary
Symbol: Tg(Igkv3-5*-MYC)DLoxP4Plbe
Name: transgene insertion DLoxP4, P Leif Bergsagel
MGI ID: MGI:6856591
Synonyms: Tg(Igkv3-5*DLoxP-MYC)4Plbe, Vk*MYCDLoxP, VkMYCDLoxP
Transgene: Tg(Igkv3-5*-MYC)DLoxP4Plbe  Location: unknown  Genetic Position: Chr14, Syntenic
Alliance: Tg(Igkv3-5*-MYC)DLoxP4Plbe page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
  Tg(Igkv3-5*-MYC)DLoxP4Plbe involves 1 genes/genome features (Gm41210) View all
 
Tg(Igkv3-5*-MYC)DLoxP4Plbe expresses 1 gene
 
Mutation detailsThe mouse promoter drives B cell-specific expression of the human MYC coding sequence (exons 2 and 3; Genbank vector). A codon mutation generates a STOP codon at the third codon (TCG to TAG) and prevents expression of MYC. The codon substitution created a DGYW motif, a known preferential target sequence for somatic hypermutation, that can activate MYC translation following sporadic reversion. This vector lacks the loxP site found in Tg(Igkv3-5*-MYC)24Plbe. Line 4 inserted at chr14:74838906-74848613 (mm39) with deletion of intervening region. (J:94077, J:131912)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory