Doc2g^tm1.2Aljg
Targeted Allele Detail

Summary

• Symbol: Doc2g^tm1.2Aljg
• Name: double C2, gamma; targeted mutation 1.2, Alexander J Groffen
• MGI ID: MGI:6856664
• Synonyms: Doc2c^null
• Gene: Doc2g Location: Chr19:4053385-4057005 bp, + strand Genetic Position: Chr19, 3.72 cM, cytoband A
• Alliance: Doc2g^tm1.2Aljg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-7 were flanked by loxP sites. An FRT-flanked neomycin resistance gene was inserted upstream of the first loxP site. Flp-mediated recombination removed the neomycin resistance gene. Exons 3-7 were deleted via cre-mediated recombination. (J:317639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Doc2g Mutation: 11 strains or lines available

References

• Original: J:317639 Bourgeois-Jaarsma Q, et al., Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons. Mol Cell Neurosci. 2021 Apr;112:103613
• All: 1 reference(s)