Top3b^{Gt(pU-21T)Krib}
Gene trapped Allele Detail

Summary

• Symbol: Top3b^{Gt(pU-21T)Krib}
• Name: topoisomerase (DNA) III beta; gene trap pU-21T, Ki-Hoan Nam
• MGI ID: MGI:6856816
• Synonyms: Top3beta^-
• Gene: Top3b Location: Chr16:16688600-16710854 bp, + strand Genetic Position: Chr16, 10.46 cM, cytoband B1
• Alliance: Top3b^{Gt(pU-21T)Krib} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317740
• Parent Cell Line: KTPU8 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The insertion site of the gene trap vector (pU-21T) on the genome in the embryonic stem (ES) cell line KTPU8 was confirmed to be between 1330 and 1331 base pairs of intron 1. (J:317740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top3b Mutation: 47 strains or lines available

References

• Original: J:317740 Rahman FU, et al., Topoisomerase IIIbeta Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice. Int J Mol Sci. 2021 Nov 26;22(23)
• All: 1 reference(s)