Sbf1^em1Frobi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sbf1^em1Frobi
• Name: SET binding factor 1; endonuclease-mediated mutation 1, Fred Robinson
• MGI ID: MGI:6860354
• Synonyms: Mtmr5^-
• Gene: Sbf1 Location: Chr15:89172439-89199514 bp, - strand Genetic Position: Chr15, 44.79 cM, cytoband F1
• Alliance: Sbf1^em1Frobi page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two CRISPR guide RNAs triggered cuts in both exon 1 and exon 25, leading to a 14-kb deletion that eliminates exons 2-24 and fuses exon 1 to 25. The protein is out-of-frame, causing a premature stop codon in exon 25. (J:94077)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sbf1 Mutation: 43 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 2 reference(s)