Lgals3^em1(cre)Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lgals3^em1(cre)Cya
• Name: lectin, galactose binding, soluble 3; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6861775
• Synonyms: Lgals3-Cre, Lgals3^em1(cre)Cgen
• Gene: Lgals3 Location: Chr14:47611317-47623624 bp, + strand Genetic Position: Chr14, 24.6 cM, cytoband C1
• Alliance: Lgals3^em1(cre)Cya page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Recombinase)
• Mutation: Insertion
• Lgals3^em1(cre)Cya expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lgals3 (MGI:96778)

• Mutation details: A rox-flanked STOP, herpesvirus internal ribosomal entry site followed by a Cre recombinase was integrated into the endogenous Lgals3 locus after the stop codon in exon 6. A rox-flanked-STOP inserted before the IRES can be removed by dre recombinase allowing the expression cre recombinase from endogenous Lgals3 promoter. (J:318676)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lgals3 (mouse) Summary of all recombinase alleles driven by Lgals3. Comparative matrix view of recombinase activities Alliance mouse Lgals3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgals3 Mutation: 26 strains or lines available

References

• Original: J:318676 Alencar GF, et al., Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. Circulation. 2020 Nov 24;142(21):2045-2059
• All: 1 reference(s)