Zkscan3^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Zkscan3^tm1.2Itl
• Name: zinc finger with KRAB and SCAN domains 3; targeted mutation 1.2, inGenious Targeting Laboratory
• MGI ID: MGI:6863904
• Gene: Zkscan3 Location: Chr13:21571173-21586925 bp, - strand Genetic Position: Chr13, 7.78 cM, cytoband A3.1
• Alliance: Zkscan3^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:318724
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted upstream of exon 3 an FRT-flanked neomycin resistance cassette with a a 3' loxP site and downstream of exon 5 a loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 3 through 5. (J:318724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zkscan3 Mutation: 34 strains or lines available

Notes

ES cells = iTK HF4 129S/SvEv x C57BL/6

References

• Original: J:318724 Ouyang X, et al., ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression. Lab Invest. 2021 Nov;101(11):1467-1474
• All: 1 reference(s)