Cfap61^em1Mngx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cfap61^em1Mngx
• Name: cilia and flagella associated protein 61; endonuclease-mediated mutation 1, Mingxi Liu
• MGI ID: MGI:6864090
• Synonyms: Cfap61^-
• Gene: Cfap61 Location: Chr2:145776704-146056959 bp, + strand Genetic Position: Chr2, 71.28 cM
• Alliance: Cfap61^em1Mngx page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1-bp and 10-bp deletion in exon 4. Western blot and immunofluorescence analysis confirmed the absence of protein expression in testes of homozygous mutant mice. (J:319365)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfap61 Mutation: 63 strains or lines available

References

• Original: J:319365 Liu S, et al., CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Development. 2021 Dec 1;148(23):dev199805
• All: 1 reference(s)