Mpv17l^em1Riida
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mpv17l^em1Riida
• Name: Mpv17 transgene, kidney disease mutant-like; endonuclease-mediated mutation 1, Reiko Iida
• MGI ID: MGI:6865789
• Gene: Mpv17l Location: Chr16:13721025-13767483 bp, + strand Genetic Position: Chr16, 9.64 cM, cytoband B1-B2
• Alliance: Mpv17l^em1Riida page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 2 deleted 295 bp. (J:319850)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpv17l Mutation: 20 strains or lines available

References

• Original: J:319850 Iida R, et al., Deficiency of M-LP/Mpv17L leads to development of beta-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-beta pathways. Biochim Biophys Acta Mol Basis Dis. 2022 Mar 1;1868(3):166318
• All: 1 reference(s)