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Gpx4tm5Marc
Targeted Allele Detail
Summary
Symbol: Gpx4tm5Marc
Name: glutathione peroxidase 4; targeted mutation 5, Marcus Conrad
MGI ID: MGI:6874619
Synonyms: Gpx4cys
Gene: Gpx4  Location: Chr10:79883000-79892273 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Gpx4tm5Marc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:255340
Parent Cell Line:  IDG3.2 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Single point mutation
 
Mutation detailsExon 3 was replaced with a modified one in which a point mutation (UGA to UGC) results in the substitution of the catalytically active selenocysteine to a cysteine. A loxP-flanked neomycin resistance cassette was inserted downstream of exon 7. GPX4-specific activity is undetectable in homozygous tissues using PCOOH as substrate. (J:255340)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpx4 Mutation:  82 strains or lines available
References
Original:  J:255340 Ingold I, et al., Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018 Jan 25;172(3):409-422.e21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory