Lrrc23^em2Mngx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc23^em2Mngx
• Name: leucine rich repeat containing 23; endonuclease-mediated mutation 2, Mingxi Liu
• MGI ID: MGI:6877115
• Synonyms: Lrrc23^delta2
• Gene: Lrrc23 Location: Chr6:124746826-124756690 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Lrrc23^em2Mngx page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5'-GCAATCAGCTTCGGAGTGCT-3' and 5'-GATCTGGTTGTAGGAAAAGC-3' generated a 49-bp deletion in exon 4. (J:320661)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc23 Mutation: 28 strains or lines available

References

• Original: J:320661 Zhang X, et al., LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice. J Cell Sci. 2021 Oct 15;134(20):jcs259381
• All: 1 reference(s)