Palm^tm1.2Kili
Targeted Allele Detail

Summary

• Symbol: Palm^tm1.2Kili
• Name: paralemmin; targeted mutation 1.2, Manfred W Kilimann
• MGI ID: MGI:6883588
• Synonyms: Palm^-
• Gene: Palm Location: Chr10:79629406-79656730 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Palm^tm1.2Kili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237034
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted upstream of exon 5 a loxP site and downstream of exon 5 an FRT-flanked neomycin resistance cassette and 3' loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 5. Western blot analysis demonstrated that protein expression is undetectable in the brain of homozygous mutant mice. (J:237034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Palm Mutation: 29 strains or lines available

Notes

ES cell = B-D6 (C57BL/6N)

References

• Original: J:237034 Albrecht I, et al., Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis. Angiogenesis. 2013 Oct;16(4):795-807
• All: 2 reference(s)