Rps2^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Rps2^tm1.1Geno
• Name: ribosomal protein S2; targeted mutation 1.1, Genoway
• MGI ID: MGI:6883670
• Synonyms: Rps2-A226Y
• Gene: Rps2 Location: Chr17:24939037-24940901 bp, + strand Genetic Position: Chr17, 12.51 cM, cytoband A3.3
• Alliance: Rps2^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321029
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct floxed inserted into the first coding exon a floxed neomycin resistance and STOP cassette and replaced exon 3 was a modified one containing a GCC to TAC mutation that results in the amino acid substitution alanine with tyrosine at position 226 (A226Y). Cre-mediated recombination removed the selection cassette. (J:321029)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps2 Mutation: 23 strains or lines available

References

• Original: J:321029 Moore J, et al., Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice. Commun Biol. 2021 Jun 8;4(1):703
• All: 2 reference(s)