Pgr^{em1(flpo)Shah}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pgr^{em1(flpo)Shah}
• Name: progesterone receptor; endonuclease-mediated mutation 1, Nirao Shah
• MGI ID: MGI:6885881
• Synonyms: PR^Flpo
• Gene: Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Pgr^{em1(flpo)Shah} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Pgr^{em1(flpo)Shah} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pgr (MGI:97567)

• Mutation details: Using CRISPR/Cas9-mediated homologous recombination, the 2A-Flpo was inserted into the 3'UTR in exon 8 of the Pgr gene. (J:321365)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pgr (mouse) Summary of all recombinase alleles driven by Pgr. Comparative matrix view of recombinase activities Alliance mouse Pgr gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pgr Mutation: 75 strains or lines available

References

• Original: J:321365 Knoedler JR, et al., A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022 Feb 17;185(4):654-671.e22
• All: 1 reference(s)