Esr1^{em1(flpo)Shah}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Esr1^{em1(flpo)Shah}
• Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Nirao Shah
• MGI ID: MGI:6885884
• Synonyms: Esr1^Flpo
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^{em1(flpo)Shah} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Esr1^{em1(flpo)Shah} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Esr1 (MGI:1352467)

• Mutation details: Using CRISPR/Cas9-mediated homologous recombination, the 2A-Flpo was inserted into the 3'UTR in exon 10 of the Esr1 gene. (J:321365)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Esr1 (mouse) Summary of all recombinase alleles driven by Esr1. Comparative matrix view of recombinase activities Alliance mouse Esr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:321365 Knoedler JR, et al., A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022 Feb 17;185(4):654-671.e22
• All: 2 reference(s)