Taf1btm1d(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Taf1btm1d(EUCOMM)Hmgu |
Name: |
TATA-box binding protein associated factor, RNA polymerase I, B; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6887478 |
Synonyms: |
Taf1bdelta |
Gene: |
Taf1b Location: Chr12:24548580-24608570 bp, + strand Genetic Position: Chr12, 8.49 cM, cytoband A3
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Alliance: |
Taf1btm1d(EUCOMM)Hmgu page
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Mutant Cell Lines: |
HEPD0596_3_G02, HEPD0596_3_H01 |
Germline Transmission: |
Earliest citation of germline transmission:
J:321558
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 24558604 of Chromosome 12 upstream of the critical exons 4 and 5 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 4 and 5 at position 24560225. The critical exons 4 and 5 are thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene. Cre-mediated recombination deleted exons 4 and 5. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:321558)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Taf1b Mutation: |
36 strains or lines available
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Original: |
J:321558 Tremblay MG, et al., Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome. PLoS Genet. 2022 Feb;18(2):e1009644 |
All: |
1 reference(s) |
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