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Taf1btm1d(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Taf1btm1d(EUCOMM)Hmgu
Name: TATA-box binding protein associated factor, RNA polymerase I, B; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:6887478
Synonyms: Taf1bdelta
Gene: Taf1b  Location: Chr12:24548580-24608570 bp, + strand  Genetic Position: Chr12, 8.49 cM, cytoband A3
Alliance: Taf1btm1d(EUCOMM)Hmgu page
Mutation
origin
Mutant Cell Lines:  HEPD0596_3_G02, HEPD0596_3_H01
Germline Transmission:  Earliest citation of germline transmission: J:321558
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 24558604 of Chromosome 12 upstream of the critical exons 4 and 5 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 4 and 5 at position 24560225. The critical exons 4 and 5 are thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene. Cre-mediated recombination deleted exons 4 and 5. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:321558)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Taf1b Mutation:  36 strains or lines available
References
Original:  J:321558 Tremblay MG, et al., Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome. PLoS Genet. 2022 Feb;18(2):e1009644
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory