Lyz2^em3(cre)Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lyz2^em3(cre)Smoc
• Name: lysozyme 2; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
• MGI ID: MGI:6887678
• Synonyms: C57BL/6-Lyz2^em1(Cre)Smoc, Lysm-Cre
• Gene: Lyz2 Location: Chr10:117113446-117118177 bp, - strand Genetic Position: Chr10, 65.34 cM
• Alliance: Lyz2^em3(cre)Smoc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Lyz2^em3(cre)Smoc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lyz2 (MGI:96897)

• CRISPR/Cas9 technology inserted a cre expression cassette into the gene. (J:238766, J:321587)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz2 (mouse) Summary of all recombinase alleles driven by Lyz2. Alliance mouse Lyz2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyz2 Mutation: 40 strains or lines available

References

• Original: J:321587 Ai K, et al., Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages. Cell Death Dis. 2022 Feb 8;13(2):125
• All: 10 reference(s)