Neu2^em1Kyp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Neu2^em1Kyp
• Name: neuraminidase 2; endonuclease-mediated mutation 1, Kyoungsook Park
• MGI ID: MGI:6887912
• Gene: Neu2 Location: Chr1:87501749-87525567 bp, + strand Genetic Position: Chr1, 44.44 cM, cytoband D
• Alliance: Neu2^em1Kyp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 14-bp deletion. (J:321653)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neu2 Mutation: 22 strains or lines available

References

• Original: J:321653 Oh M, et al., Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo. Sci Rep. 2022 Feb 25;12(1):3216
• All: 1 reference(s)