Tshz1^tm1(flpo)Zjh
Targeted Allele Detail

Summary

• Symbol: Tshz1^tm1(flpo)Zjh
• Name: teashirt zinc finger family member 1; targeted mutation 1, Z Josh Huang
• MGI ID: MGI:6888001
• Synonyms: Tshz1-2A-FlpO
• Gene: Tshz1 Location: Chr18:84029752-84105831 bp, - strand Genetic Position: Chr18, 57.53 cM
• Alliance: Tshz1^tm1(flpo)Zjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296899
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tshz1^tm1(flpo)Zjh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tshz1 (MGI:1346031)

• Mutation details: The allele was generated by inserting a 2A-flpo expression cassette immediately after the STOP codon of the Tshz1 gene by homologous recombination in ES cells. (J:296899)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tshz1 (mouse) Summary of all recombinase alleles driven by Tshz1. Comparative matrix view of recombinase activities Alliance mouse Tshz1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tshz1 Mutation: 52 strains or lines available

References

• Original: J:296899 Xiao X, et al., A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. Cell. 2020 Oct 1;183(1):211-227.e20
• All: 1 reference(s)