Rab7b^tm1Ciphe
Targeted Allele Detail

Summary

• Symbol: Rab7b^tm1Ciphe
• Name: RAB7B, member RAS oncogene family; targeted mutation 1, Centre d'ImmunoPhenomique
• MGI ID: MGI:6888140
• Gene: Rab7b Location: Chr1:131616433-131643177 bp, + strand Genetic Position: Chr1, 57.18 cM
• Alliance: Rab7b^tm1Ciphe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:321707
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 5 and downstream of exon 5 a modified 3' UTR with an IRES sequence, mTFP1 reporter gene, loxP site and FRT site. (J:321707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab7b Mutation: 20 strains or lines available

References

• Original: J:321707 Vestre K, et al., Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. J Cell Sci. 2021 Sep 15;134(18):jcs259221
• All: 1 reference(s)