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Rab7btm1Ciphe
Targeted Allele Detail
Summary
Symbol: Rab7btm1Ciphe
Name: RAB7B, member RAS oncogene family; targeted mutation 1, Centre d'ImmunoPhenomique
MGI ID: MGI:6888140
Gene: Rab7b  Location: Chr1:131616433-131643177 bp, + strand  Genetic Position: Chr1, 57.18 cM
Alliance: Rab7btm1Ciphe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:321707
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change, Reporter)
Mutation:    Insertion
 
Mutation detailsThe targeting construct inserted a loxP site upstream of exon 5 and downstream of exon 5 a modified 3' UTR with an IRES sequence, mTFP1 reporter gene, loxP site and FRT site. (J:321707)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rab7b Mutation:  20 strains or lines available
References
Original:  J:321707 Vestre K, et al., Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. J Cell Sci. 2021 Sep 15;134(18):jcs259221
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory