Mgl2tm1.1(cre)Aiwsk
Targeted Allele Detail
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Symbol: |
Mgl2tm1.1(cre)Aiwsk |
Name: |
macrophage galactose N-acetyl-galactosamine specific lectin 2; targeted mutation 1.1, Akiko Iwasaki |
MGI ID: |
MGI:7254996 |
Synonyms: |
Mgl2-cre |
Gene: |
Mgl2 Location: Chr11:70021155-70028376 bp, + strand Genetic Position: Chr11, 42.99 cM
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Alliance: |
Mgl2tm1.1(cre)Aiwsk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:321812
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Mgl2tm1.1(cre)Aiwsk expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting vector contains an IRES-EGFP-cre-polyA cassette followed by an FRT-flanked neomycin resistant cassette (in reverse orientation) inserted into the 3' untranslated region (downstream of the stop codon in the last coding exon (exon 10). Flp-mediated recombination removed the FRT-flanked neo cassette. EGFP is not detectable by flow cytometry, and is not believed to be visible by direct fluorescence. Sporadic low-level expression of cre is observed in germ cells or during early embryogenesis. In addition, homozygous mice have little to no expression of MGL2 protein.
(J:321812)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Mgl2
(mouse)
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Original: |
J:321812 Tatsumi N, et al., Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry. Sci Immunol. 2021 Dec 10;6(66):eabg0336 |
All: |
1 reference(s) |
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