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Mgl2tm1.1(cre)Aiwsk
Targeted Allele Detail
Summary
Symbol: Mgl2tm1.1(cre)Aiwsk
Name: macrophage galactose N-acetyl-galactosamine specific lectin 2; targeted mutation 1.1, Akiko Iwasaki
MGI ID: MGI:7254996
Synonyms: Mgl2-cre
Gene: Mgl2  Location: Chr11:70021155-70028376 bp, + strand  Genetic Position: Chr11, 42.99 cM
Alliance: Mgl2tm1.1(cre)Aiwsk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:321812
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mgl2tm1.1(cre)Aiwsk expression driven by 1 gene
 
Mutation detailsThe targeting vector contains an IRES-EGFP-cre-polyA cassette followed by an FRT-flanked neomycin resistant cassette (in reverse orientation) inserted into the 3' untranslated region (downstream of the stop codon in the last coding exon (exon 10). Flp-mediated recombination removed the FRT-flanked neo cassette. EGFP is not detectable by flow cytometry, and is not believed to be visible by direct fluorescence. Sporadic low-level expression of cre is observed in germ cells or during early embryogenesis. In addition, homozygous mice have little to no expression of MGL2 protein. (J:321812)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mgl2 (mouse)
Summary of all recombinase alleles driven by Mgl2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgl2 Mutation:  27 strains or lines available
References
Original:  J:321812 Tatsumi N, et al., Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry. Sci Immunol. 2021 Dec 10;6(66):eabg0336
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory