Clptm1^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clptm1^em1(IMPC)Tcp
• Name: cleft lip and palate associated transmembrane protein 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:7256882
• Synonyms: Clptm1^-
• Gene: Clptm1 Location: Chr7:19365505-19398955 bp, - strand Genetic Position: Chr7, 9.93 cM, cytoband A2
• Alliance: Clptm1^em1(IMPC)Tcp page
• IMPC: Clptm1 gene page

Clptm1^em1(IMPC)Tcp/Clptm1^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulas. Mutants fail to hatch from the zona pellucida and are dead after 3 days in culture.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted 1,081 bp. (J:322048)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Clptm1 Mutation: 35 strains or lines available

References

• Original: J:322048 The Centre for Phenogenomics, Direct Data Submission for The Centre for Phenogenomics Alleles. MGI Direct Data Submission. 2022
• All: 4 reference(s)