Abhd2^em1Lshko
Endonuclease-mediated Allele Detail

Summary

• Symbol: Abhd2^em1Lshko
• Name: abhydrolase domain containing 2; endonuclease-mediated mutation 1, Polina Lishko
• MGI ID: MGI:7257779
• Synonyms: Abhd2^-
• Gene: Abhd2 Location: Chr7:78923002-79015257 bp, + strand Genetic Position: Chr7, 44.96 cM, cytoband D2
• Alliance: Abhd2^em1Lshko page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted exon 6. The deletion removed a serine (S208) important for the catalytic function of ABHD2, and resulted in a frameshift and a premature stop codon in exon 7. Western blotting and IHC analysis confirmed the complete absence of protein expression in the ovaries of homozygous mutant mice. (J:322075)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abhd2 Mutation: 46 strains or lines available

References

• Original: J:322075 Bjorkgren I, et al., Alpha/Beta Hydrolase Domain-Containing Protein 2 Regulates the Rhythm of Follicular Maturation and Estrous Stages of the Female Reproductive Cycle. Front Cell Dev Biol. 2021;9:710864
• All: 3 reference(s)