Ndnf^em1Nou
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ndnf^em1Nou
• Name: neuron-derived neurotrophic factor; endonuclease-mediated mutation 1, Noriyuki Ouchi
• MGI ID: MGI:7259868
• Gene: Ndnf Location: Chr6:65648595-65689307 bp, + strand Genetic Position: Chr6, 30.29 cM
• Alliance: Ndnf^em1Nou page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 134 bp deletion in exon 2. RT-PCR confirmed absence of mRNA in the gastrocnemius muscle and Western blot analysis confirmed absence of protein in the plasma. (J:322617)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndnf Mutation: 28 strains or lines available

References

• Original: J:322617 Ozaki Y, et al., Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy. Biochem Biophys Res Commun. 2022 Feb 19;593:5-12
• All: 1 reference(s)