Aqp4^tm1Gghu
Targeted Allele Detail

Summary

• Symbol: Aqp4^tm1Gghu
• Name: aquaporin 4; targeted mutation 1, Gang Hu
• MGI ID: MGI:7261160
• Synonyms: AQP4^-
• Gene: Aqp4 Location: Chr18:15522553-15544039 bp, - strand Genetic Position: Chr18, 8.74 cM
• Alliance: Aqp4^tm1Gghu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112451
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced part of the exon 1 coding sequence. (J:112451)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp4 Mutation: 46 strains or lines available

References

• Original: J:112451 Fan Y, et al., Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice. J Neurosci Res. 2005 Nov 15;82(4):458-64
• All: 59 reference(s)