Ggct^em1.2Smoc
Targeted Allele Detail

Summary

• Symbol: Ggct^em1.2Smoc
• Name: gamma-glutamyl cyclotransferase; endonuclease-mediated mutation 1.2, Shanghai Model Organisms Center
• MGI ID: MGI:7261305
• Synonyms: Ggct^tm1.2Smoc
• Gene: Ggct Location: Chr6:54962080-54969947 bp, - strand Genetic Position: Chr6, 27.26 cM
• Alliance: Ggct^em1.2Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting inserted a loxP site upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:322242)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ggct Mutation: 10 strains or lines available

References

• Original: J:322242 He Z, et al., Ggct (gamma-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival. Br J Haematol. 2021 Oct;195(2):267-275
• All: 2 reference(s)