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Cpeb3em1Gaoxu
Endonuclease-mediated Allele Detail
Summary
Symbol: Cpeb3em1Gaoxu
Name: cytoplasmic polyadenylation element binding protein 3; endonuclease-mediated mutation 1, Xu Gao
MGI ID: MGI:7261344
Synonyms: Cpeb3 mut
Gene: Cpeb3  Location: Chr19:36998691-37186000 bp, - strand  Genetic Position: Chr19, 32.08 cM
Alliance: Cpeb3em1Gaoxu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 mediated recombination with guide RNAs targeting exon 2 created a 2 bp (TC) deletion. Western blot analysis confirmed the absence of protein expression in brain, ovary and testis lysates from homozygous mutant mice. (J:313356, J:323073)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpeb3 Mutation:  36 strains or lines available
References
Original:  J:313356 Zhang H, et al., CPEB3-mediated MTDH mRNA translational suppression restrains hepatocellular carcinoma progression. Cell Death Dis. 2020 Sep 23;11(9):792
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory