Cpeb3^em1Gaoxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cpeb3^em1Gaoxu
• Name: cytoplasmic polyadenylation element binding protein 3; endonuclease-mediated mutation 1, Xu Gao
• MGI ID: MGI:7261344
• Synonyms: Cpeb3 mut
• Gene: Cpeb3 Location: Chr19:36998691-37186000 bp, - strand Genetic Position: Chr19, 32.08 cM
• Alliance: Cpeb3^em1Gaoxu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated recombination with guide RNAs targeting exon 2 created a 2 bp (TC) deletion. Western blot analysis confirmed the absence of protein expression in brain, ovary and testis lysates from homozygous mutant mice. (J:313356, J:323073)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpeb3 Mutation: 36 strains or lines available

References

• Original: J:313356 Zhang H, et al., CPEB3-mediated MTDH mRNA translational suppression restrains hepatocellular carcinoma progression. Cell Death Dis. 2020 Sep 23;11(9):792
• All: 2 reference(s)