Cep128^em3Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cep128^em3Fzh
• Name: centrosomal protein 128; endonuclease-mediated mutation 3, Feng Zhang
• MGI ID: MGI:7261354
• Synonyms: CEP128^R222Q
• Gene: Cep128 Location: Chr12:90965266-91351183 bp, - strand Genetic Position: Chr12, 44.08 cM, cytoband E
• Alliance: Cep128^em3Fzh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation orthologous to the mutation found in human patients associated with male infertility (R222Q). (J:323071)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cep128 Mutation: 54 strains or lines available

References

• Original: J:323071 Zhang X, et al., CEP128 is involved in spermatogenesis in humans and mice. Nat Commun. 2022 Mar 16;13(1):1395
• All: 1 reference(s)